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. 2016 Sep 26;7(46):75539–75550. doi: 10.18632/oncotarget.12265

Figure 5. SC09 delays MM tumor growth with well tolerance in vivo.

Figure 5

A. Mononuclear cells isolated from bone marrow collected from healthy donors or MM patients were treated with SC09 (10 μM) for 24 h before being plated in triplicate in MethoCult GF H4434 medium and cultured for 3 weeks before counting the colony forming units. B. The curves of tumor sizes over the experiment. *, p < 0.05; $, p < 0.01. C. The tumor tissues were excised at the end of the experiment. D. The weight of the excised tumor tissues was measured. E. The curve of body weights over the experiment period. F. White blood cells (WBC), red blood cells (RBC), platelets (PLT) and hemoglobin (HGB) were measured at the end of the experiment. G. The excised tumor tissues were prepared for immunoblotting against p-STAT3, STAT3 and GAPDH. H. Statistical analysis for p-STAT3/STAT3 of Figure G.