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. 2016 Sep 28;7(46):75648–75658. doi: 10.18632/oncotarget.12315

Figure 1. Recurrent copy number variation in IPO11 identified by whole-exome sequencing and confirmed by qPCR and FISH.

Figure 1

Copy number ratio (Tbas vs. Tsup) determined by whole-exome sequencing of samples from 3 MIBC patients (sample IDs: 002, 005, and 114; T: superficial tumor, and J: basal tumor); the arrows indicate the locations of IPO11. A. The IPO11 copy number ratio was increased in sample 002; B. this ratio was unchanged in sample 005; C. and this ratio was increased in sample 114. IPO11 copy number variations were confirmed in samples 002, 005 and 114 by quantitative polymerase chain reaction D. and fluorescence in situ hybridization E-H. The orange fluorescent spot indicates the IPO11 gene (5q12.1), the green fluorescent spot represents the AHRR gene (5p15.3), and the arrowhead indicates the nucleus with an increased IPO11 copy number. The microscopic data from immunohistochemical analysis of IPO11 are presented at the bottom of the figure I-L.