Table 1. KEGG enrichment analysis of the genes with functional mutations.
| KEGG pathway | Number of genes in the KEGG pathway | Number of differentially expressed genes | Expected number in the pathway | Ratio of enrichment | Raw P value | Adjusted P value | |
|---|---|---|---|---|---|---|---|
| Tsup vs. Normal | Notch signaling pathway | 47 | 8 | 0.86 | 9.33 | 1.99E-06 | 0.0003 |
| Focal adhesion | 200 | 14 | 3.65 | 3.84 | 2.11E-05 | 0.0009 | |
| Cell cycle | 124 | 11 | 2.26 | 4.86 | 1.82E-05 | 0.0009 | |
| Long-term potentiation | 70 | 8 | 1.28 | 6.26 | 4.13E-05 | 0.0014 | |
| Calcium signaling pathway | 177 | 12 | 3.23 | 3.72 | 0.0001 | 0.0022 | |
| Hypertrophic cardiomyopathy (HCM) | 83 | 8 | 1.51 | 5.28 | 0.0001 | 0.0022 | |
| Prostate cancer | 89 | 8 | 1.62 | 4.93 | 0.0002 | 0.0024 | |
| Glioma | 65 | 7 | 1.19 | 5.9 | 0.0002 | 0.0024 | |
| Amino sugar and nucleotide sugar metabolism | 48 | 6 | 0.88 | 6.85 | 0.0002 | 0.0024 | |
| p53 signaling pathway | 68 | 7 | 1.24 | 5.64 | 0.0002 | 0.0024 | |
| Tight junction | 132 | 10 | 2.41 | 4.15 | 0.0002 | 0.0024 | |
| Metabolic pathways | 1130 | 38 | 20.62 | 1.84 | 0.0003 | 0.0033 | |
| Starch and sucrose metabolism | 54 | 6 | 0.99 | 6.09 | 0.0004 | 0.0037 | |
| Pathways in cancer | 326 | 16 | 5.95 | 2.69 | 0.0004 | 0.0037 | |
| Ribosome biogenesis in eukaryotes | 80 | 7 | 1.46 | 4.79 | 0.0007 | 0.0061 | |
| Tbas vs. Tsup | Adherens junction | 73 | 2 | 0.04 | 56.26 | 0.0006 | 0.0012 |
| Tight junction | 132 | 2 | 0.06 | 31.12 | 0.0019 | 0.0019 |