Table 2. Cox regression analysis of parameters potentially influencing cancer-specific survival and cancer-free survival in 114 patients with urothelial carcinoma of the bladder.
| Parameters | Cancer-specific survival | Cancer-free survival | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |
| Univariate Cox regression analysis | ||||||
| Age (≥ 65 vs. < 65) | 1.027 | 0.992-1.064 | 0.131 | 1.031 | 0.997-1.066 | 0.077 |
| Sex (male vs. female) | 0.641 | 0.265-1.551 | 0.324 | 0.707 | 0.294-1.698 | 0.438 |
| Tumor stage (T2-T4 vs. Tis-T1) | 1.616 | 0.735-3.552 | 0.232 | 1.375 | 0.671-2.820 | 0.384 |
| Tumor grade (high vs. low) | 2.458 | 0.335-18.053 | 0.377 | 1.331 | 0.318-5.565 | 0.695 |
| Lymphatic invasion (yes vs. no) | 3.493 | 1.678-7.271 | 0.001 | 3.137 | 1.523-6.460 | 0.002 |
| Lymph node metastasis (yes vs. no) | 3.119 | 1.533-6.347 | 0.002 | 2.768 | 1.376-5.565 | 0.004 |
| IPO11 expression (high vs. low) | 3.891 | 1.515-9.992 | 0.005 | 3.537 | 1.487-8.415 | 0.004 |
| Multivariate Cox regression analysis* | ||||||
| Age (≥ 65 vs. < 65) | - | - | - | 1.035 | 0.999-1.072 | 0.056 |
| Lymphatic invasion (yes vs. no) | 2.039 | 0.803-5.179 | 0.134 | 1.942 | 0.820-4.598 | 0.131 |
| Lymph node metastasis (yes vs. no) | 1.621 | 0.654-4.017 | 0.297 | 1.682 | 0.724-3.909 | 0.227 |
| IPO11 expression (high vs. low) | 3.191 | 1.222-8.335 | 0.018 | 2.972 | 1.235-7.150 | 0.015 |
Abbreviations: HR, hazard ratio; CI, confidence interval.
*
multivariate analysis of cancer-specific and cancer-free survival included only those parameters with a P value of ≤0.10 in univariate analysis.