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. 2016 Sep 30;7(46):75685–75697. doi: 10.18632/oncotarget.12353

Figure 4. IL13 played a significant role in PGN's differential effect on irradiated intestine and tumor.

Figure 4

A. Flowcytomix assays using bead technology were utilized to detect cytokine production (μg cytokine/mg tissue weight) in intestinal and tumor tissues that were untreated, treated with PGN alone, radiation alone, or radiation + PGN at 9 days after IR. B. Western blot analysis of mTOR and phospho-mTOR expression in HCT116 cells following treatment with radiation alone or radiation + PGN in the presence or absence of IL13 (0.8 and 1.2 ng/mL), IL13 neutralizing antibody (0.12 and 0.2 μg/mL), or TNF-α neutralizing antibody (0.04 and 0.08 μg/mL).