Table 1. Number of protein pairs through all the selection process for obtaining the DIRP.

	DK STRING Exp	CT STRING Exp	DK PINA	CT PINA
# initial pairs	351	351	435	435
#pairs after phylogenetic boundary	323	323	396	396
# DIRP	106	82	113	86
% pairs	30	23	26	20

The first row indicates the number of protein pairs that were initially analyzed in each system (algorithm and dataset used). The second row shows the number of pairs after applying the phylogenetic threshold for distant pairs (normalized phylogenetic distance ≥ 1.7). The third row contains the number of DIRP finally selected, after filtering by the normalized network distance threshold (p-value ≤ 0.05) established by means of random models and specified in Table S2 in Supplementary material. The last row indicates the percentages of DIRP over the total number of Ras pairs initially found.