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. 2016 Oct 12;7(46):76006–76020. doi: 10.18632/oncotarget.12579

Figure 6. IL-23 mediates the growth of ovarian cancer xenografts in vivo.

Figure 6

A, B. A2780-derived CD133+ CSLCs (5 × 105 per mouse) transfected with Control shRNA (vector) or IL-23p19-shRNA were injected subcutaneously into female nude mice and observed for 3 months before mice were killed. Tumor incidence (A) and survival rate (B) in each group are shown. C-E. A2780-derived CD133+ CSLCs (5 × 105 per mouse) pretreated with IL-23 inhibitor ST-5326 (10μM) or DMSO for 48h were injected subcutaneously into female nude mice and observed for 2 months before mice were killed. Tumor incidence (C), xenografts tumor volumes (D) and weight of xenografts tumor (E) at day 62 are shown. Experiments were performed three times and data are expressed as mean ± SD. *P<0.05.