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. 2016 Oct 12;7(46):76036–76046. doi: 10.18632/oncotarget.12582

Figure 1. SOX17 expression is negatively correlated with MAML3 in EC patient samples and cell lines.

Figure 1

IHC and real-time PCR were used to detect SOX17 and MAML3, respectively, in different samples. IHC analysis of SOX17, MAML3 and Wnt pathway proteins in normal endometrium, atypical hyperplasia and endometrial cancer tissues A. Error bar=50um, *P<0.05. Real-time PCR analysis of SOX17, MAML3 and Wnt pathway proteins in endometrial cancer cells B. Low SOX17 levels were correlated with increased MAML3, CyclinD1, c-Myc and β-catenin expression in EC cell lines. SOX17 and MAML3 were inversely correlated in human endometrial cancer cells (R=−0.91, P=0.001) C. In Kaplan-Meier analyses, patients with low SOX17-expressing (n=52, P=0.024) D. or high MAML3-expressing (n=76, P=0.022) E. tumors had poor overall survival. Results represent at least three separate experiments.