Figure 4. Human prostate cancer cell lines with an increasingly mesenchymal phenotype have an enhanced in vivo capacity for metastasis to distant organs.

Incidence of metastasis to distant organs following orthotopic injection of PC-3M, PC-3, LNCaP C4-2B, and LNCaP human prostate cancer cell lines. Data are presented as the percentage of mice per cell line per timepoint with detectable distant metastases to the lung, liver diaphragm, intestines, kidney, and/or spleen/pancreas (n=7-39 mice/group) as assessed by gross observation at necropsy (left panel) and microscopic histological examination (right panel) of tissues.