Table 3. IC50 value (μM) of combination treatment and drug-dose reduction (Fa=0.5).

		MDV3100-TKI258		MDV3100-BKM120		MDV3100-RAD001		TKI258-BKM120		TKI258-RAD001		BKM120-RAD001		Cabazitaxel –BKM120		Cabazitaxel –TKI258		Cabazitaxel –RAD001
LNCaP	Combination IC50	0.15	0.46	0.11	0.35	0.07	0.21	0.32	0.32	0.33	0.33	0.60	0.60	0.89	0.45	0.35	0.70	0.64	1.29
	Fold reduction	42.07	6.61	57.36	9.23	90.14	19.29	9.50	10.09	9.21	12.27	5.38	6.75	2.02	7.18	5.14	4.34	2.81	3.14
PC3	Combination IC50							1.24	0.82	1.73	0.86	1.64	0.65	1.41	0.71	1.31	0.99	2.01	2.01
	Fold reduction							2.08	3.44	1.49	6.35	1.72	8.40	4.48	3.97	4.82	2.61	3.14	2.72
22Rv1	Combination IC50							0.09	0.15	0.57	0.2	0.01	0.04
	Fold reduction							10.78	1.53	4.96	5.1	6.00	5.75

MDV3100 combinations for PC3 and 22Rv1, and Cabazitaxel combinations for 22Rv1, were not determined