Table 4. Dose response matrix of BKM120+TKI2598 combination in PC3 cells.

	BKM120
	Conc (μM)		50	25	12.5	6.25	3.12	1.56	0.78	0.39
TKI258		Viability (%)	1%	8%	36%	39%	42%	64%	78%	84%
	50	4%	3.92	2.57	1.89	1.55	1.39	1.30	1.25	1.23
	25	15%	2.62	1.61	1.14	0.88	0.76	0.71	0.69	0.65
	12.5	26%	2.38	1.42	0.96	0.67	0.56	0.48	0.47	0.43
	6.25	51%	2.29	1.33	0.75	0.49	0.34	0.28	0.24	0.24
	3.12	67%	2.04	1.08	0.60	0.35	0.23	0.17	0.13	0.13
	1.56	76%	1.69	0.89	0.48	0.26	0.16	0.13	0.12	0.12
	0.781	83%	1.54	0.78	0.39	0.21	0.14	0.11	0.09	0.26
	0.39	93%	1.48	0.76	0.39	0.23	0.13	0.12	0.15	0.03

Antagonism (CI > 1, red)

Additive (CI = 1, yellow)

Synergism (CI < 1, green)