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. 2016 Aug 10;7(46):76274–76290. doi: 10.18632/oncotarget.11187

Figure 6. Cytotoxicity of MAIT cells.

Figure 6

A. and B. LAK activity of MAIT cells. Freshly isolated PBMCs (1 × 106/well) were cocultured with K562 cells for 4 hours in the presence of the supernatant harvested from purified MAIT cells stimulated for 12 hours with or without PMA (100 ng/ml) and IM (1 μM). C. and D. Cytotoxicity of purified MAIT cells. Following stimulation with or without PMA (100 ng/ml) and IM (1 μM), MAIT cells (1 × 106/well) were then cocultured with K562 cells. LAK activity A. and cytotoxicity C. were then determined as the percentage of apoptotic K562 cells and respresentative flow cytometry results are presented. Data in B. and D. were obtained from 5 HCs. Values are expressed as the mean ± SEM. *, P < 0.05, **, P < 0.005 by paired t test.