Table 1. The Characteristics of the patients.

	Before matching			After matching
	Monotherapy	Doublet	P-valuea	Monotherapy	Doublet	P-valuea
Total	107	394		107	107
Age(years)
<65	76	309	.108	76	76	1.000
≥65	31	85		31	31
Gender
Male	73	252	.412	73	75	.767
Female	34	142		34	32
T stage
T1	8	16	.116	8	11	.542
T2	18	41		18	17
T3	25	114		25	32
T4	56	222		56	47
N stage
N0(0)	48	80	.000b	48	36	.377
N1(1-2)	21	78		21	24
N2(3-6)	15	93		15	21
N3(≥7)	23	143		23	26
TNM Stage
I	22	19	.000b	22	14	.251
II	37	128		37	46
III	48	247		48	47
Type of resection
Total gastrectomy	9	59	.134	9	17	.094
Subtotal gastrectomy	97	335		97	90
Histology
Well differentiated	32	97	.580	32	29	.867
Poorly differentiated	52	194		52	56
Signet-ring cell	17	82		17	18
Others	6	21		6	4
Location of tumor
Cardia	34	104	.306	34	37	.340
Antrum	49	174		49	10
Corpus	15	57		15	44
Others	9	59		9	16

^aChi-square test;

^bstatistically significant;

T stage: Depth of primary tumor invasion; N stage: Regional lymph nodes classification; Others in Histology: Mucinous adenocarcinoma and adenosquamous carcinoma; Others in Location tumor: Mixture of cardia and corpus or mixture of corpus and antrum or the whole stomach.