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Zn2+ induces uptake of rhSOD3 via heparin binding domain. HaCaT (A) and 293T cells (B) were cultured with purified rhSOD3 or rh209E at various concentrations (0, 10, 25, 50 μM) of CuSO4/ZnCl2. Amounts of rhSOD3 or rh209E in HaCaT and 293T cells were compared between media and cell lysates by western blot analysis.
