. Author manuscript; available in PMC: 2017 Mar 8.

Published in final edited form as: J Am Chem Soc. 2015 Oct 23;137(43):13972–13979. doi: 10.1021/jacs.5b09980

Table 4. Sequential Pd-Catalyzed Isomerization of Branched Allylic Carbonates 6 and Ir-Catalyzed Asymmetric Allylic Substitutions^a.

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Reaction conditions. Step 1: allylic carbonate 6 (0.4 mmol), Pd(dba)₂ (1 mol %), PPh₃ (2 mol %), THF, rt. Step 2: enol silane 2 or 3 (0.8 mmol, 2.0 equiv), [Ir(cod)Cl]₂ (2 mol %), (R_a,R_c,R_c)-L (4 mol %), KF (1 equiv), 18-crown-6 (1 equiv), THF (0.8 mL), 50 °C, 12 h.

Table 4. Sequential Pd-Catalyzed Isomerization of Branched Allylic Carbonates 6 and Ir-Catalyzed Asymmetric Allylic Substitutionsa.

Table 4. Sequential Pd-Catalyzed Isomerization of Branched Allylic Carbonates 6 and Ir-Catalyzed Asymmetric Allylic Substitutions^a.