Table I. Anchor-based approach to determining the MID for the CASI.

Baseline Clinician Severity (Numeric rating) – 10 Cats	Absolute difference [95% CI]	Effect Size* [95% CI]
[0,10] vs [11,20]	0.48 [0.00, 0.98]	0.26 [0.01, 0.53]
[11,20] vs [21,30]	1.19 [0.64, 1.75]	0.57 [0.29, 0.85]
[21,30] vs [31, 40]	1.13 [0.40, 1.83]	0.49 [0.18, 0.80]
[31,40] vs [41,50]	0.66 [-0.03, 1.37]	0.25 [0.05, 0.56]
[41,50] vs [51,60]	0.60 [-0.18, 1.42]	0.22 [0.08, 0.53]
[51,60] vs [61,70]	0.85 [-0.25, 1.94]	0.31 [0.10, 0.72]
[61,70] vs [71,80]	0.87 [-0.36, 2.01]	0.27 [0.12, 0.67]
[71,80] vs [81,90]	1.88 [0.02, 3.57]	0.57 [0.01, 1.13]
[81,90] vs [91,100]	1.65 [-1.20, 4.11]	0.51 [0.64, 1.65]
10 cats: Weighted Average	0.90	0.36

^*Effect sizes were computed by using the Hedges g-statistic: 0.2 = small effect, 0.5 = medium effect, and 0.8 = large effect.