Table 1.
Nitroblue tetrazolium (NBT)-test results and clinical information.
| Infant ID | Age (in weeks) | Gender | NBT-positive neutrophils | Interpretation | Infants preventive Thx | Breastfeeding | Mother start of antiretroviral therapy | |||
|---|---|---|---|---|---|---|---|---|---|---|
| Non-stimulated (%) | Stimulated (%) | Before pregnancy | During pregnancy | Therapy | ||||||
| HEU1 | 10 | Male | 86.7 | 88 | Normal neutrophils | Nevirapine/co-trimoxazole | No | No | Yes @ 6 months | EFV-TDF-LVD |
| HEU2 | 6 | Male | 60 | 89 | Normal neutrophils | Nevirapine/co-trimoxazole | No | Yes | No | TDF-3TC-EFV |
| HEU3 | 12 | Female | 75 | 85 | Normal neutrophils | Zidovidine/co-trimoxazole | No | Yes | No | 3TC-Zido-EFV |
| HEU4 | 6 | Female | 73 | 85 | Normal neutrophils | Yes | No | TDF-3TC-EFV | ||
| HEU5 | 12 | Female | 47 | 92.7 | Normal neutrophils | Zidovidine/co-trimoxazole | No | Yes | No | |
| HEU6 | 6 | Male | 78 | 91 | Normal neutrophils | Nevirapine/co-trimoxazole | No | Yes | No | |
| HEU7 | 6 | Female | 9.3 | 12.7 | Impaired reactive oxygen species (ROS) production | Nevirapine/co-trimoxazole | No | No | No | None |
| HEU8 | 10 | Male | 8.7 | 4.7 | Impaired ROS production | Nevirapine/co-trimoxazole | No | No | Yes @ 4 months | TDF-FTC-EFV |
| HEU9 | 10 | Male | 9.5 | 7 | Impaired ROS production | Nevirapine/co-trimoxazole | No | No | Yes @ 4 months | TDF-FTC-EFV |
| HEU10 | 6 | Male | 14 | 35 | Impaired ROS production | Nevirapine | No | Yes | NO | |
| HEU11 | 6 | Female | 48.3 | 38 | Impaired ROS production | Nevirapine/co-trimoxazole | No | No | Yes @ 6 months | |
| HEU12 | 6 | Male | 37 | 34 | Impaired ROS production | Nevirapine/co-trimoxazole | No | No | Yes @ 2 months | |
| HEU13 | 6 | Female | 6.3 | 97.7 | Normal neutrophils | Nevirapine/co-trimoxazole | No | Yes | ABC-3TC-LPV-RTV | |
| HEU14 | 12 | Male | 14 | 23 | Impaired ROS production | Nevirapine/co-trimoxazole | Yes (for 3 months) | No | Yes @ 6 months | TDF-3TC-EFV |
| HEU15 | 6 | Male | 93.7 | 94.7 | Normal neutrophils | NO | Yes | No | Yes @ 3 months | TDF-FTC-EFV |
| HEU16 | 6 | Male | 91.7 | 98 | Normal neutrophils | Nevirapine/co-trimoxazole | No | Yes | No | |
| HEU17 | 8 | Male | 96 | 99 | Normal neutrophils | Nevirapine | No | No | Yes @ 3 months | TDF-FTC-EFV |
| HEU18 | 7 | Male | 75 | 81.3 | Normal neutrophils | Nevirapine/co-trimoxazole | No | Yes @ 4 months | ||
| HEU19 | 6 | Female | 74.7 | 73.3 | Normal neutrophils | Nevirapine/co-trimoxazole | No | No | Yes @ 4 months | |
| HEU20 | 6 | Male | 86 | 88 | Normal neutrophils | Nevirapine/co-trimoxazole | No | Yes | No | |
| HEU21 | 6 | Female | 33.3 | 30.5 | Impaired ROS production | Nevirapine/co-trimoxazole | No | Yes | No | |
| HEU22 | 6 | Male | 3 | 3 | Impaired ROS production | Nevirapine/co-trimoxazole | No | Yes | No | TDF-3TC-EFV |
| HEU23 | 6 | Male | 74.7 | 67 | Normal neutrophils | Nevirapine/co-trimoxazole | No | Yes | No | |
| HEU24 | 6 | Male | 67 | 80 | Normal neutrophils | Nevirapine/co-trimoxazole | No | Yes | No | AZT-3TC-NVP |
| HEU25 | 6 | Male | 74 | 83.7 | Normal neutrophils | Nevirapine/co-trimoxazole | No | No | Yes @ 7 months | AZT-3TC-NVP |
| HU1 | 12 | Female | 56 | 72.7 | Normal neutrophils | NA | NA | NA | NA | NA |
| HU2 | 8 | Female | 53 | 92 | Normal neutrophils | NA | NA | NA | NA | NA |
| HU3 | 6 | Male | 76.3 | 95.3 | Normal neutrophils | NA | NA | NA | NA | NA |
Bold font indicates Impaired ROS production.