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. 2017 Mar 9;11:112. doi: 10.3389/fnins.2017.00112

Figure 3.

Figure 3

PD98059 regulates the expression of p-ERK1/2 and FosB-ΔFosB in the striatum. (A) Levels of ERK1/2, p-ERK1/2, and ΔFosB were relatively quantified in the DA-denervated striatum from each group of rats by Western blotting. (B,C) Analysis of differences in p-ERK1/2 vs. ERK1/2 and ΔFosB vs. β-actin in the lesioned striatum from each group. *p < 0.05, **p < 0.01 (one-way ANOVA followed by Tukey HSD and LSD post-hoc test, N = 4/group). Error bars represent SEM. (D) Immunohistochemical images of FosB-ΔFosB in dorsal striatum on the lesioned side from rats of each group (Normal, PD, LID, LID + Vehicle, LID + PD98059). Scale bar is 100 μm. (E) Analysis of differences in FosB-ΔFosB positive cells counts in each group. **p < 0.01 (one-way ANOVA followed by Tukey HSD and LSD post-hoc test, N = 4/group). Error bars represent SEM.