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. 2017 Mar 9;11:112. doi: 10.3389/fnins.2017.00112

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Copyright © 2017 Chen, Nie, Han, Ma, Xu, Zhang, Papa and Cao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PD98059-specific co-expression modules across LID+PD98059 group, LID + Vehicle group, and LID groups. (A,B) All candidates (including protein coding genes and lncRNA) in the dataset (37,177 transcripts in microarray) were hierarchically clustered under unsupervised average linkage and classified into 45 modules labeled by color. (C) The module membership (MM) vs. gene significance (GS) plots for steelblue and red module showed that MM and GS are highly correlated (GS P < 0.05). (D) The steelblue and red module contained candidates negatively and positively correlated to the PD98059 treatment, respectively. (E) GO enrichment analysis about transcripts in steel blue and red module (P < 0.05).