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. 2017 Mar 9;10:44. doi: 10.3389/fnmol.2017.00044

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Copyright © 2017 Munoz, Kumar, Oh, Conley, Wang, Failla and Wagner.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Acute CSF Cortisol by Survival Status (N = 117). The open circles indicate survivors and closed circles are non-survivors. Data for CSF Cortisol (ng/mL) were averaged within survival category each day. Error bars indicate standard error of the mean. On days 2–4, CSF Cortisol levels were significantly (p < 0.05) elevated among non-survivors compared to survivors. (B) Acute CSF BDNF by Survival Status (N = 117). The open circles indicate survivors and closed circles are non-survivors. Data for CSF BDNF (ng/mL) were averaged within survival category each day. Error bars indicate standard error of the mean. On days 3 and 5, CSF BDNF levels were significantly (p < 0.05) elevated among non-survivors compared to survivors. There was a trend toward significant difference in levels on day 0 (p = 0.078); there were no significant differences in CSF BDNF levels for any other day.