Table 1.
Demographic and clinical characterization of the cohort.
| Overall (n = 117) | Survivors (n = 91) | Non-survivors (n = 26) | P-value | |
|---|---|---|---|---|
| Age in years (mean ± SE) | 36.0 ± 1.5 | 32.40 (1.4) | 48.42 (3.7) | <0.001* |
| Sex, Men (%) | 99 (85.3) | 77 (85.6) | 22 (84.6) | 0.905 |
| GCS, median (IQR) | 7 (6-7) | 7 (6-8) | 6 (6-7) | 0.043* |
| Mechanism of injury, n (%) | 0.034* | |||
| Automobile | 60 (52.2) | 41 (45.6) | 7 (26.9) | |
| Motorcycle | 28 (24.3) | 22 (24.4) | 6 (23.1) | |
| Fall/jump | 19 (16.5) | 10 (11.1) | 9 (34.6) | |
| Other | 8 (7.0) | 17 (18.9) | 4 (15.4) | |
| Length of hospital stay in days (mean ± SE) | 21.2 ± 1.0 | 23.01 (1.1) | 14.68 (1.7) | 0.002* |
| Injury Severity Score Non-head (mean ± SE) | 13.26 (1.0) | 12.99 (1.0) | 14.18 (2.3) | 0.822 |
| Neurological injury type, n (%) | ||||
| SDH | 81 (69.2) | 60 (65.9) | 21 (80.8) | 0.148 |
| DAI | 36 (30.8) | 33 (36.3) | 3 (11.5) | 0.016* |
| EDH | 14 (12.0) | 11 (12.1) | 3 (11.5) | 0.939 |
| Contusion | 52 (44.4) | 35 (38.5) | 17 (65.4) | 0.015* |
| IVH | 39 (33.3) | 32 (35.2) | 7 (30.0) | 0.432 |
| ICH | 40 (34.2) | 30 (33.0) | 10 (38.5) | 0.602 |
| SAH | 82 (70.1) | 61 (67.0) | 21 (80.8) | 0.177 |
| rs6265, n (%) | 0.617 | |||
| Val/Val | 68 (58.1) | 54 (59.3) | 14 (53.9) | |
| Met-carrier | 49 (41.9) | 37 (40.7) | 12 (46.2) | |
| rs7124442, n (%) | 0.520 | |||
| T/T | 61 (52.1) | 46 (50.6) | 15 (57.7) | |
| C-carrier | 56 (47.9) | 45 (49.5) | 11 (42.3) | |
| BDNF mean (SE) | 0.19 (0.01) | 0.18 (0.01) | 0.21 (0.02) | 0.045* |
| Cortisol mean (SE) | 24.28 (1.3) | 21.01 (1.20) | 35.75 (3.45) | <0.0001* |
*
p ≤ 0.05.