Table 2.

Prior knowledge of BDNF and mortality association mediated by cortisol level among all subjects and stratified by 75th quartile of age.

	All subjects (N = 185)		Age ≤ 48 years (N = 139)		Age >48 years (N = 46)
Pathwaya	β (SE)	P-value	β (SE)	P-value	β (SE)	P-value
BDNF to Cortisol (Logistic)b	1.35 (0.48)	0.005	1.94 (0.61)	0.001	0.30 (0.75)	0.694
Cortisol to mortality (Cox)	1.13 (0.40)	0.005	1.00 (0.56)	0.095	1.27 (0.57)	0.026
BDNF to mortality-Total Effect (Cox)	0.65 (0.30)	0.033	1.03 (0.42)	0.015	0.30 (0.41)	0.457
BDNF to mortality-Direct Effect (Cox)c	0.47 (0.38)	0.217	0.54 (0.65)	0.407	0.48 (0.49)	0.324

^aAll pathways adjusted for 75th percentile age (at 48 year old).

^bWeekly average CSF BDNF in ng/mL (≥75th percentile, <75th percentile); CSF cortisol using trajectory analysis grouping (low vs. high).

^cAlso adjusted for cortisol trajectory grouping (low vs. high).

Bolded p-values indicate statistical significance.