Table 4.
Odds Ratios and 95% Confidence Intervals for CSF BDNF and cortisol levels.
| GRS = 0 (N = 29)a | GRS = 1 (N = 71) | GRS = 2 (N = 17) | ||||
|---|---|---|---|---|---|---|
| Cortisol TRAJ Group 2 vs. 1b | OR (95% CI)c | Cortisol TRAJ Group 2 vs. 1b | OR (95% CI) | Cortisol TRAJ Group 2 vs. 1b | OR (95% CI) | |
| BDNF 75th pct. | 15/14 | 2.46 (0.30, 16.13) | 23/48 | 6.50 (1.70, 24.81) | 6/11 | 9.00 (0.28, 285.51) |
| P trend | 0.285 | 0.006 | 0.213 | |||
Individual Models stratified by Gene Risk Scores.
a
GRS score: 0 = Val/Val (rs6265) and T/T (rs7124442); 1 = Val/Val (rs6265), C-carriers (rs7124442) or Met-Carriers (rs6265), T/T (rs7124442); 2 = Met-Carriers (rs6265) and C-Carriers (rs7124442).
b
Number of subjects in each cortisol trajectory group (Group 2 has higher cortisol level).
c
Adjusted for binary age (≤48 vs. >48 years old).
Bolded p-value indicates statistical significance.