Skip to main content
. 2017 Feb 21;21(2):241–249. doi: 10.4196/kjpp.2017.21.2.241

Fig. 3. LDD175 activates hSLo3+hLRRC52 currents.

Fig. 3

(A) Left panel: Extracellular application of 30 µM LDD175 enhances hSLo3+hLRRC52 currents. Activation was calculated as the percentage of current remaining after treatment relative to that prior to treatment at 116 mV. Right panel: Representative traces showing I~V relationships before (●) and after (○) treatment. (B) Left panel: Concentration-response curve for LDD175-induced activation of hSlo3+hLRRC52. Right panel: Representative I~V traces showing changes in current with the application of LDD175. (C) Activation of hSlo3+hLRRC52 current by 30 µM LDD175, as evidenced by changes in membrane potential after treatment. Left panel: Treatment with 30 µM LDD175 induces membrane potential hyperpolarization. Right panel: Representative continuous trace showing changes in membrane potential during the application of 30 µM LDD175. The number of cells is indicated in a bar graph. **p<0.01.