Fig. 4. LDD175 potentiates K⁺ currents in both rSlo1-transfected and hSlo3+hLRRC52–co-transfected cells.

(A) The application of 10 µM LDD175 causes a rightward shift in the rSlo1 steady-state G~V relationship (left panel), significantly decreases V_h values (middle panel), and increases the amplitude of step currents. (B, C) External application of 10 µM LDD175 significantly increases the relative conductivity of hSlo3+hLRRC52 at pH 7.3 (B, left panel) and pH 8.0 (C, left panel), and increases the amplitude and changes the shape of step currents (right panels). The number of cells is indicated in a bar graph. ^**p<0.01