Inclusion criteria
Population	Adults or children with chronic hepatitis B or C in whom assessment of liver fibrosis is indicated
Intervention	The Virtual Touch™ Quantification (VTq) software application used with the Siemens Virtual Touch™ Tissue Imaging systems (the Acuson S2000™ or S3000™ ultrasound platforms)
Outcomes	Correlation in assessment of stage of liver disease Sensitivity and specificity (using AUROC) in assessment of liver fibrosis Correlation in assessment of stage of fibrosis using Metavir score Use of antiviral drugs Quality-of-life measures Hospital bed usage and length of stay Requirement for liver biopsy Device-related adverse events
Study design	Diagnostic accuracy studies
Language restrictions	English language only Foreign language papers with English abstracts could be included
Search dates	2009–current
Exclusion criteria
Population	Mixed patient cohort, use of a fibrosis score other than Metavir, overlapping cohorts with other identified populations
Study design	Case studies, editorials, letters, reviews
Interventions	No restriction

AUROC area under receiver operating characteristic