Figure 4.

Interictal subgraphs are selectively sensitive to the SOZ. A, Distribution of average SOZ sensitivity of subgraphs in each cluster, ranked in decreasing order, from each patient (N = 22). SOZ sensitivity of true SOZ labels in blue and of permuted SOZ labels in gray. We observed a significant effect of SOZ sensitivity for real SOZ labels compared with permuted SOZ labels for clusters 1, 2, 3, and 6 (*p < 0.05, **p < 0.01, ***p < 0.001; Bonferroni corrected for multiple comparisons). These results demonstrate that functional interactions between brain regions are heterogeneously sensitive to dysfunction in the SOZ, depending on cluster-specific subgraph stereotypes. B, Importantly, we observed that subgraphs of cluster 1 were significantly sensitive to connections within the SOZ, while subgraphs of cluster 6 were significantly sensitive to connections outside the SOZ. An example of subgraphs from cluster 1 (left) and cluster 6 (right) are shown here. Connections between SOZ nodes are shown in the top-left box, and connections between non-SOZ nodes are shown in the bottom-right box.