Table 2.

Risk of bias in studies of active TB incidence comparing IGRA with TST in children, immunocompromised people and recently arrived people from countries with a high incidence of TB

First author, Year	Study Participation	Study Attrition	Prognostic Factor Measurement	Outcome/Construct Measurement	Study Confounding	Statistical Analysis and Reporting	Total ROB
Children
Diel, 2011 [11]	Low	Low	Moderate	Moderate	Low	Low	Moderate ROB
Mahomed, 2011 [13]	Moderate	Moderate	Moderate	Moderate	High	Low	Moderate ROB
Metin Timur 2014 [14]	High	High	Moderate	Moderate	High	High	High ROB
Noorbakhsh 2011 [15]	High	High	High	Moderate	High	High	High ROB
Song, 2014 [16]	Low	Moderate	Low	High	Moderate	Low	Moderate ROB
Immunocompromised
Elzi, 2011 [12]	High	Low	Low	Moderate	High	Low	High ROB
Kim, 2011 [17]	Low	Low	Low	Low	Moderate	Low	Low ROB
Kim, 2015 [18]	Low	Low	Low	Low	High	Low	Low ROB
Lee, 2009 [19]	High	Low	Low	Moderate	High	Low	High ROB
Lee, 2014 [22]	High	Moderate	Moderate	Moderate	Low	Low	Moderate ROB
Lee, 2015 [23]	Low	Low	Moderate	Low	High	Low	Low ROB
Milman, 2014 [20]	Low	Low	Moderate	Low	Low	Low	Low ROB
Moon, 2013 [21]	Moderate	Low	Moderate	Moderate	Moderate	Low	Moderate ROB
Sester, 2014 [24]	Low	Low	Moderate	Low	High	Low	Moderate ROB
Sherkat, 2014 [25]	High	High	Moderate	High	High	Moderate	High ROB
Recent arrivals from countries with a high incidence of TB
Harstad, 2010 [26]	High	Low	High	Moderate	High	High	High ROB
Kik, 2010 [27]	Low	Low	Low	Low	Low	Low	Low ROB

IGRA interferon gamma release assay, ROB risk of bias, TST tuberculin skin test

Risk of bias item responses (per domain, overall): high, moderate or low