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. 2017 Mar 9;9:17. doi: 10.1186/s13195-017-0245-y

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — cGMP, but not cAMP, levels in CSF of AD patients are reduced. Box plots comparing CSF levels of cGMP (a) and cAMP (b) in CSF of patients with AD compared with control patients measured by ELISA. (a) cGMP levels in the CSF of AD patients were significantly reduced compared with control subjects (p = 0.017). (b) cAMP levels in the CSF of AD patients were not altered. Mann–Whitney U test. AD Alzheimer’s disease, cAMP cyclic adenosine-3',5'-monophosphate, cGMP cyclic guanosine-3',5'-monophosphate, CSF cerebrospinal fluid