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. 2017 Jan 19;188(1):109–126. doi: 10.1111/cei.12906

Figure 5.

Figure 5

In‐vivo production of proinflammatory cytokines after the challenge of BALB/c mice with detoxified listeriolysin O (dtLLO). Groups of female BALB/c mice (n = 11 each group) were challenged intraperitoneally (i.p.) with physiological saline solution (control) dtLLO (20 μg per mouse) or lipopolysaccharide (LPS) (20 μg per mouse). The levels of interleukin (IL)‐6 and IL‐12 in the serum of immunized mice were measured by enzyme‐linked immunosorbent assay (ELISA) after 1 and 2 h post‐challenge. Significant P‐values are shown as follows: **P < 0·01; ***P < 0·001.