Figure 2.
Properdin deficiency protects mice from 5‐fluorouracil (5‐FU)‐induced mucositis. (a) Weight loss during 5‐FU treatments. Data is the mean percentage of each animal's weight at the start of the experiment ± standard error of the mean (s.e.m.) (n = 6 mice/group). (b) Inflamed PKO mice registered significantly less rectal bleeding and (c,d) intestinal inflammation, compared to wild‐type (WT) mice. Each dot represents a single mouse and the line represents the median score. *P < 0·05 versus inflamed WT mice. (e) Neutrophil infiltration into the 5‐FU‐treated mouse intestine. Similar numbers of neutrophils were detected in the two strains. (f) Periodic acid‐Schiff (PAS)‐positive cells/10 intact villi/section and averaged for all mice within a treatment group. The data are the mean ± s.e.m. of four or five mice.