Table 3.
Multivariable determinants of adhering to medication in the Colitis Once Daily Asacol (CODA) trial
| Purpose | Variable | Adjusted odds ratio | 95% Confidence interval | p value | |
|---|---|---|---|---|---|
| Lower | Upper | ||||
| Associated with disease status at 12 months (relapsed/still in remission) | Intervention (OD arm compared to TDS arm) | 2.61 | 0.75 | 9.03 | 0.131 |
| Age at baseline (≥65 years compared to <65 years) | 2.42 | 0.27 | 21.70 | 0.430 | |
| Length of remission (≥12 months compared to <12 months) | 1.05 | 0.29 | 3.75 | 0.940 | |
| Endoscopy findings at baseline (non-normal compared to normal) | 0.31 | 0.10 | 1.01 | 0.053 | |
| Associated with adherence to study medication | Smoking status at baseline (current smoker compared to non-smoker) | 1.31 | 0.25 | 6.79 | 0.076 |
| Smoking status at baseline (ex-smoker compared to non-smoker) | 11.46 | 1.40 | 94.01 | ||
OD once daily, TDS three times daily