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. 2017 Mar 9;7:44123. doi: 10.1038/srep44123

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(a) Bim phosphorylation in BRAF^WT HCC cells 24 hours after BRAF inhibition with sorafenib. (b) Bim degradation in BRAF^WT HCC cells 48 hours after BRAF inhibition with sorafenib. Inhibition of ERK increases apoptosis (c) and decreases Bim degradation after sorafenib treatment in BRAF^WT HCC cells in vitro (d) and in spontaneously arising HCCs in Mst1^−/−Mst2^Flox/− mice in vivo (e).