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. 2017 Mar 9;7:44053. doi: 10.1038/srep44053

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Soluble meprin α and membrane bound meprin β can generate sIL-6R. The cleavage however occurs at distinct sites when compared to ADAM10/17 mediated shedding. The sIL-6R can in all cases bind to IL-6 and gp130 on another cell and induce trans-signaling. Shedding of meprin β by ADAM10/17 might be a regulatory step to prevent generation of sIL-6R by membrane bound meprin β.