Figure 7. Simultaneous ¹³C-HP and ex vivo imaging:

The compact design of the setup enabled SAMBADENA next to a small rat post mortem in the sensitive volume of the magnet (a,b). Within seconds, the ¹³C-tracer HEP was polarized to ∼17% at a concertation of 22 mM. Without leaving the magnet, ∼330 μl of the tracer were injected into the rat, and strong ¹³C signal with a maximum SNR of 113 was observed by MRI acquired in 0.5 s (c). Subsequently, a T₂-weighted ¹H-MRI (d) and ¹H Zero-Echo-Time (ZTE) MRI were recorded. Co-registration of ¹H and ¹³C-data revealed the location of the tracer, in the reaction chamber and surrounding the heart of the animal (e,f). The isocenter of the magnet is the center of the images. R, reactor; FOV, field of view; M, Model Solution M3; 1, 2, 3: lines for pressure relieve, pH₂ supply and pH₂ injection, respectively.