Table 3. Clinical Characteristics of R834C-WRN Homozygotes.
| ID | Kinship | Age | Gender | Short Stature1 | Grey Hair2 | Thin Hair | Ame-tropia2 | DM2 | High BP3 | Other Characteristics | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1401 | Index | 19 | M | No | No | No | 18 | No | No | Ectomorphic somatotype; late pubarche | |
| 1402 | Sister | 18 | F | Yes | No | No | No | No | No | Thin Limbs | |
| 1903 | Parent | 56 | M | No | 50 | No | 54 | No | No | Late pubarche | |
| 2604 | Parent | 57 | M | No | No | No | 40 | No | Yes | Hypermelanosis | |
| 3104 | Uncle | 61 | M | No | 40 | No | 40 | No | No | Hair loss | |
| 3304 | Parent | 46 | M | No | 30 | No | 23 | 33 | No | Hypermelanosis | |
| 6701 | Index | 20 | M | No | 18 | No | 18 | No | Yes | Older appearance4; flat feet5 | |
| 6712 | Brother | 25 | M | No | No | No | 24 | No | No | Older appearance; early onset hair loss6; flat feet | |
| 6801 | Index | 22 | M | No | No | No | 20 | No | No | Older appearance; nail deformity; cold fingers; flat feet | |
| 7303 | Parent | 42 | M | No | No | Yes | 29 | 32 | Yes | Hypermelanosis; nail deformity; cold fingers; dyslipidemia | |
| 7309 | Uncle | 39 | M | No | 35 | Yes | 39 | 29 | No | ||
| 7502 | Parent | 58 | M | No | 54 | Yes | 55 | 58 | Yes | Early onset hair loss; atrophic skin; bird-like facies | |
| 7508 | Aunt | 59 | F | No | 48 | No | No | No | No |
1Stature was based on mid-parental height and comparison to growth charts of the Mexican population.
2Numbers indicate age of appearance of grey hair, diagnosis of ametropia (visual acuity), or onset of diabetes mellitus (DM).
3BP: blood pressure.
4Description of older appearance was based on comparison with family members and identical aged. individuals in the Mexican population.
5Flat feet diagnosed at age 3 yr in all three individuals.
6Early onset hair loss is defined as hair loss before the age of 30.