Table 1. Assessment results for each pharmacophore model.

Model	Hta	Hab	A (%)c	Y (%)d	Ne	CAIf
Model_01	173	90	90.00	52.02	1.85	1.67
Model_02	161	90	90.00	55.90	1.99	1.79
Model_03	163	89	89.00	54.60	1.94	1.73
Model_04	166	91	91.00	54.82	1.95	1.78
Model_05	167	90	90.00	53.89	1.92	1.73
Model_06	169	91	91.00	53.85	1.92	1.74
Model_07	180	91	91.00	50.56	1.80	1.64
Model_08	172	91	91.00	52.91	1.88	1.71
Model_09	168	91	91.00	54.17	1.93	1.75
Model_10	155	92	92.00	59.35	2.11	1.94

^aHt is the number of hits.

^bHa is the number of active hits.

^cA% represents the ability to identify active compounds from the external database (A% = Ha/A, while A is the number of active compounds in the external database).

^dY% represents the proportion of active hits in total hits (Y% = Ha/Ht).

^eN represents the ability to distinguish active compounds from non-active compounds (N = (Ha/Ht)/(A/D), while D is the number of compounds in the external database).

^fCAI was utilized to evaluate the models comprehensively (CAI = N × A%).