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. 2017 Mar 6;8:14378. doi: 10.1038/ncomms14378

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The DNAzyme motor was designed to respond to the intracellular miRNA miR-10b. (a) Images of MDA-MB-231 cancer cells after intracellular operation of the DNAzyme motor for 0, 5, 10, 15, 30, 45 and 60 min. 0 min refers to the time point when Mn²⁺ is added into the operating buffer. The LMM5 laser transmission setting was 85 and the laser excitation time was 185 ms for each image. (b,c) Fluorescence intensity of six cells over the 60 min operation time of the DNAzyme motor. The fluorescence intensity was measured using ImageJ 1.47. The length of the scale bar is 17 μm.