Table 3. Enriched histone modification detected with Enrichr (ENCODE Histone Modifications 2015) in the 46 selected genes.

Rank	Histone modification	P-value	adjusted P-values	Z-score	combines score
1	H3K4me1_fibroblast of dermis_hg19	1.60E-06	6.20E-04	−1.8	13.29
2	H3K4me1_bone marrow macrophage_mm9	4.90E-05	3.16E-03	−1.87	10.74
3	H3K4me1_myotube_hg19	4.90E-05	3.16E-03	−1.7	9.78
4	H3K4me1_K562_hg19	2.56E-05	3.16E-03	−1.66	9.54
5	H3K4me1_A549_hg19	3.03E-05	3.16E-03	−1.64	9.43
6	H3K4me1_skeletal muscle myoblast_hg19	4.90E-05	3.16E-03	−1.62	9.33
7	H3K4me2_K562_hg19	2.33E-04	1.00E-02	−1.74	8.03
8	H3K4me1_HepG2_hg19	2.33E-04	1.00E-02	−1.68	7.75
9	H3K4me1_HeLa-S3_hg19	2.33E-04	1.00E-02	−1.6	7.37
10	H3K4me1_fibroblast of lung_hg19	9.88E-04	2.94E-02	−1.73	6.12
11	H3K4me2_HeLa-S3_hg19	9.88E-04	2.94E-02	−1.71	6.02
12	H3K4me1_T-cell acute lymphoblastic leukaemia_hg19	9.88E-04	2.94E-02	−1.64	5.8
13	H3K27ac_osteoblast_hg19	9.88E-04	2.94E-02	−1.63	5.75
14	H3K4me3_Panc1_hg19	1.40E-03	3.61E-02	−1.59	5.27
15	H3K4me1_MEL cell line_mm9	1.39E-03	3.61E-02	−1.47	4.88
16	H3K27ac_A549_hg19	1.95E-03	4.71E-02	−1.53	4.68
17	H3K4me3_A549_hg19	2.14E-03	4.88E-02	−1.51	4.56

Only those associated with adjusted P-values less than 0.05 are listed. Bold text indicates enrichment in the K562 cell line and is used in Fig. 1.