Figure 2. Cortical atrophy patterns for three AD subtypes using the SMC dataset: MT (medial temporal-predominant), P (parietal-predominant), and D (diffuse) subtypes.

Modular organization of the subjects was achieved using defined similarity and reordered to illustrate subtyping where each square captures a subtype border. Group comparison results of cortical thicknesses between each subtype and CN was corrected using random field theory and regions with corrected p < 0.001 are visualized (p < 0.05 for the D subtype) with covariate age, gender and education. (upper row). Atrophy map shows medians of the cortical atrophy (z-scores) in each subtype (−0.6 ≤ z ≤ −0.3) (lower row).