TABLE 2—

Recent Marijuana Use Effect on Incident Total Cardiovascular Disease, Stroke or Transient Ischemic Attack, Coronary Heart Disease, and Cardiovascular Disease Mortality: CARDIA, United States, 2014

Variable	None (n = 4153)	1–9 Days (n = 573)	10–19 Days (n = 148)	≥ 20 Days (n = 239)	P for Trend
Total cardiovascular disease
No. of events	156	34	11	14
Event ratea	1.44	2.43	2.98	2.46
AHR (95% CI)b	1 (Ref)	1.05 (0.69, 1.50)	1.36 (0.60, 3.09)	0.88 (0.42, 1.82)	.78
Stroke or transient ischemic attack
No. of events	43	10	5	4
Event ratea	0.39	0.73	1.38	0.67
AHR (95% CI)b	1 (Ref)	1.25 (0.51, 3.07)	2.77 (0.83, 9.24)	1.03 (0.22, 4.78)	.69
Coronary heart disease
No. of events	78	14	5	8
Event ratea	0.72	0.96	1.46	1.43
AHR (95% CI)b	1 (Ref)	0.85 (0.40, 1.79)	1.30 (0.43, 3.95)	1.01 (0.38, 2.65)	.97
Cardiovascular disease mortality
No. of events	30	12	4	5
Event ratea	0.27	0.84	1.04	0.87
AHR (95% CI)b	1 (Ref)	1.60 (0.67, 3.85)	1.91 (0.55, 6.61)	1.20 (0.23, 6.16)	.84

Note. AHR = adjusted hazard ratio; CARDIA = the Coronary Artery Risk Development in Young Adults study; CI = confidence interval. The sample size was n = 5113. We assessed the number of participants who used marijuana over the last 30 d during the examination immediately before the date of the clinical cardiovascular event, date of death, or the last date of contact.

^aPer 1000 person-years.

^bAdjusted for age, gender, race, educational attainment, and study center as well as family history of cardiovascular disease and time-varying physical activity, body mass index, high blood pressure, diabetes, dyslipidemia, depression, smoking (pack-years), cumulative alcohol use, cumulative binge drinking episodes, and cumulative use of other illicit drugs (cocaine, crack, speed, methamphetamine, or opioids).