Figure 5.

Mean Square Fluctuations across CAP Ensembles Compared with Apo-CAP

The four ensembles are generated separately. Apo-CAP has no cAMP. The other ensembles have additional constraints (see Experimental Procedures) representing cAMP bound to chain A, cAMP bound to chain B, or cAMP bound to both chains A and B. The bound cAMP molecules are shown for reference as green sticks. Red regions indicate residues with more flexibility compared with apo-CAP, and blue regions indicate residues with less flexibility compared with apo-CAP.