Table 1.

Neuroprotective and neurodegenerative miRNAs in Alzheimer’s diseases

A. Neuroprotective miRNAs in Alzheimer’s disease
miRNAs	Status in AD	Target gene	Effect on target genes	Reference
miR-29a/b-1 cluster	Brain	BACE1/β-secretase	Upregulation	Hébert et al., 2008 [89]
miR-101	-	APP	Downregulation	Vilardo et al., 2010 [90]
miR-124	↓ brain	BACE1	Downregulation	Fang et al., 2012 [41]
miR-132/212	↓ brain	PTEN, FOXO3a and P300	Downregulation	Wong et al., 2013 [91]
miR-34	-	tau	Downregulation	Dikson et al., 2013 [92]
miR-193b	↓ hippocampus	APP	Downregulation	Liu et al., 2014 [93]
miR-188-3p	↓ brain	BACE1	Downregulation	Zhang et al., 2014 [49]
miR-339-5p	↓ brain	BACE1	Downregulation	Long et al., 2014 [50]
miR-212/132 & miR23a/b	↓ frontalcortex	sirt1	Upregulation	Weinberg et al., 2015 [94]
miR-219	↓ brain	tau	Downregulation	Santa-Maria et al., 2015 [95]
miR-16	↓ neuronal cells	APP	Downregulation	Zhang et al., 2015 [96]
Mir-29c	↓ peripheral blood	BACE1	Downregulation	Yang et al., 2015 [48]
miR-135b	↓ peripheral blood	BACE1	Downregulation	Zhang et al., 2016 [97]
miR-1229-3p	-	SORL1	Downregulation	Ghanbari et al., 2016 [98]
miR-15/107 family	↓ brain	CDK5R1	Downregulation	Moncini et al., 2016 [99]
miR-603	↑ hippocampus	LRPAP1	Downregulation	Zhang et al., 2016 [100]
miR-29	↓ brain	hBACE1	Downregulation	Pereira et al., 2016 [101]

B. Neurodegenerative miRNAs in Alzheimer’s disease
miR-26b	↑ brain cortex	Rb1	Upregulation	Absalon et al., 2013 [102]
miR-30a-5p	-	BDNF	Downregulation	Croce et al., 2013 [103]
miR-206	↑ brain	BDNF	Downregulation	Tian et al., 2014 [104]
miR-125	↑ brain	DUSP6, PPP1CA & Bcl-W	Downregulation	Banzhaf-Strathmann et al., 2014 [105]
miR-33	-	ABCA1	Downregulation	Kim et al., 2015 [67]
miR-34a	↑ brain	VAMP2, SYT1, HCN1, NR2A, GLUR1,NDUFC2,	Downregulation	Sarkar et al., 2016 [106]
miR-126	↑ brain	IRS-1 and PIK3R2	Downregulation	Kim et al., 2016 [107]