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Effect of GP-17 on PI3K/Akt phosphorylation via ERα in Ox-LDL treated HUVECs. (A,B) Phosphorylation of Akt mediated by GP-17 in Ox-LDL-induced HUVECs was abolished by pretreatment with ICI182780 or LY294002. The values are expressed as the mean ± S.E.M. from three independent experiments. # p < 0.05; ### p < 0.001 vs. Control; * p < 0.05; *** p < 0.001 vs. Ox-LDL; & p < 0.05; &&& p < 0.001 vs. GP-17 + Ox-LDL. p-Akt, phospho-protein kinase B.
