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. 2017 Feb 9;18(2):77. doi: 10.3390/ijms18020077

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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GP-17 protected HUVECs against Ox-LDL-induced oxidative stress by increasing the antioxidant enzymes and antioxidant proteins. (A) The expression of HO-1 was analyzed by immunofluorescence assays; (B,C) The expressions of antioxidant proteins mediated by GP-17 in Ox-LDL-induced HUVECs were abolished by pretreatment with ICI182780 or LY294002; (D) the levels of SOD, GSH-Px and CAT activities and MDA production mediated by GP-17 in Ox-LDL-induced HUVEC injury were determined and abolished by pretreatment with ICI182780 or LY294002. The values are expressed as the mean ± S.E.M. from three independent experiments. ^## p < 0.01; ^### p < 0.001 vs. Control; * p < 0.05; ** p < 0.01; *** p < 0.001 vs. Ox-LDL; ^& p < 0.05; ^&& p < 0.01; ^&&& p < 0.001 vs. GP-17 + Ox-LDL. HO-1, heme oxygenase 1; SOD, superoxide dismutase; GSH-Px, glutathione peroxidase; CAT, catalase; MDA, malondialdehyde.