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. 2017 Feb 9;18(2):77. doi: 10.3390/ijms18020077

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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GP-17 protected HUVECs against Ox-LDL-induced apoptosis by decreasing the ratio of Bax to Bcl-2 and controlling cleaved caspase-3 activation. (A) The expression of cleaved caspase-3 was analyzed by immunofluorescence assays; (B,C) The expression of apoptosis-inducing proteins mediated by GP-17 in Ox-LDL-induced HUVECs was abolished by pretreatment with ICI182780 or LY294002; (D) The protective effect of GP-17 against LDH release induced by Ox-LDL in HUVECs. The values are expressed as the mean ± S.E.M. from three independent experiments. ^## p < 0.01; ^### p < 0.001 vs. Control; ** p < 0.01; *** p < 0.001 vs. Ox-LDL; ^& p < 0.05; ^&& p < 0.01; ^&&& p < 0.001 vs. GP-17 + Ox-LDL.