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. 2017 Jan 25;18(2):246. doi: 10.3390/ijms18020246

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Reported functions and regulations of Mbk-1 family proteins. Honeybee Mblk-1 binds to MBE sequence in vitro, and activates transcription of the downstream gene. Mouse Mlr1 and Mlr2 also show MBE-dependent transactivation activity. Expression of Drosophila E93 is upregulated by ecdysteroid in pupal stages, likely under the control of ecdysone receptor (EcR) complex. E93 is required for expression of genes related to apoptosis and adult body patterning. Human LCoR interacts with estrogen receptor (ER) and suppresses transcription of ER target genes, but recent studies suggest that it may also act to enhance transcription of several target genes.