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. 2017 Feb 10;18(2):248. doi: 10.3390/ijms18020248

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The molecular components and structure of mitochondrial calcium uniporter (MCU). (A) The components of Homo sapiens MCU. From left to right, the schematic shows a linear overview of the predicted domain architecture of each of the seven Homo sapiens MCU components. MTS: mitochondrial targeting signal, TM: transmembrane domain, CC: coiled-coil domain, DIME: the conserved DIME motif, CAD: carboxy-terminal domain, EF: EF-hand domain, DUF1640: protein of unknown function (DUF1640); (B) The structure of Mcu-∆NTD (left) and MCUb-∆NTD (right). Upper: front view of Mcu and MCUb show both of them have three distinct layers, down: top view displays the calcium pore formed by five transmembrane domains of Mcu (left) or MCUb (right) (http://swissmodel.expasy.org/repository/) [25,28]; (C) Cartoon of Homo sapiens MCU in the inner membrane of mitochondria.