. 2017 Jan 26;18(2):257. doi: 10.3390/ijms18020257

Table 4.

Significant associations of tagged single-nucleotide polymorphisms (SNPs) from genome-wide association study (GWAS)-associated genes with pre-supplementation methylation levels (n = 35 individuals).

Gene	SNP	CpG Site ^a	Position	p Value ^b
IQCJ	rs4501157	cg09784347	CHR 3, 158786963	0.0457
		cg17255703	CHR 3, 158787141	0.0077
		cg10461878	CHR 3, 158904717	0.0035
	rs2044704 ^c	cg16975599	CHR 3, 158962761	0.0001 *
	rs1962071 ^c	cg16975599	CHR 3, 158962761	0.0004 *
	rs7634829	cg17255703	CHR 3, 158787141	0.0025
	rs2621294	cg26659665	CHR 3, 158786242	0.0238
		cg10461878	CHR 3, 158904717	0.0301
		cg12919294	CHR 3, 158962196	0.0152
	rs17782879 ^c	cg16975599	CHR 3, 158962761	0.0362
	rs1868414 ^c	cg16975599	CHR 3, 158962761	0.0086
	rs2595260 ^c	cg16975599	CHR 3, 158962761	0.0001 *
	rs9827242 ^c,d	cg23982461	CHR 3, 158955027	0.0077
	rs9827242 ^c,d	cg16975599	CHR 3, 158962761	0.0056
	rs1449009 ^c,e	cg16975599	CHR 3, 158962761	0.0001 *
	rs2621309 ^c,e	cg16975599	CHR 3, 158962761	0.0001 *
	rs61332355 ^c,d,e	cg16975599	CHR 3, 158962761	0.0002 *
NXPH1	rs6956210	cg06328127	CHR 7, 8469546	0.0089
	rs6956210	cg11642377	CHR 7, 8480779	0.0048
	rs2107779 ^c	cg20378002	CHR 7, 8477029	0.0109
		cg08897422	CHR 7, 8666902	0.0059
		cg21001050	CHR 7, 8791686	0.0006
	rs12216689 ^c	cg00852549	CHR 7, 8473457	0.0120
		cg17278735	CHR 7, 8476834	0.0127
		cg01933308	CHR 7, 8483569	0.0388
		cg13611822	CHR 7, 8483710	0.0404
	rs6963644	cg07462540	CHR 7, 8473279	0.0375
		cg00852549	CHR 7, 8473457	0.0327
		cg06444755	CHR 7, 8473990	0.0266
		cg20378002	CHR 7, 8477029	0.0123
		cg23075337	CHR 7, 8481460	0.0051
		cg22287800	CHR 7, 8634300	0.0245
		cg08897422	CHR 7, 8666902	0.0259
	rs1013868 ^c	cg24785946	CHR 7, 8473234	0.0266
		cg00852549	CHR 7, 8473457	0.0103
		cg09225457	CHR 7, 8481460	0.0495
	rs4318981	cg06981279	CHR 7, 8477156	0.0452
		cg07511564	CHR 7, 8481036	0.0211
		cg01933308	CHR 7, 8483569	0.0474
		cg02614372	CHR 7, 8486611	0.0261
	rs7801099	cg24785946	CHR 7, 8473234	0.0238
		cg00852549	CHR 7, 8473457	0.0095
		cg09225457	CHR 7, 8479893	0.0289
	rs4725120	cg06981279	CHR 7, 8477156	0.0425
	rs4725120	cg01994275	CHR 7, 8480586	0.0122
	rs1859275	cg22339356	CHR 7, 8473385	0.0153
		cg01354961	CHR 7, 8473462	0.0148
		cg07511564	CHR 7, 8481036	0.0247
	rs1012960	cg07462540	CHR 7, 8473279	0.0437
		cg00852549	CHR 7, 8473457	0.0282
		cg06981279	CHR 7, 8477156	0.0093
	rs11767429 ^c	cg00288806	CHR 7, 8476521	0.0287
	rs11767429 ^c	cg21001050	CHR 7, 8791686	0.0252
	rs4333500	cg00852549	CHR 7, 8473457	0.0479
	rs4333500	cg12597389	CHR 7, 8482235	0.0391
	rs7799856	cg24785946	CHR 7, 8473234	0.0343
		cg00399951	CHR 7, 8476098	0.0378
		cg00288806	CHR 7, 8476521	0.0270
		cg21001050	CHR 7, 8791686	0.0470
	rs13221144	cg08897422	CHR 7, 8666902	0.0448
	rs7805772 ^c	cg12597389	CHR 7, 8482235	0.0445
	rs2349780 ^c	cg19469357	CHR 7, 8474830	0.0264
		cg06056929	CHR 7, 8476128	0.0017
		cg00288806	CHR 7, 8476521	0.0167
		cg15285250	CHR 7, 8482107	0.0229
	rs11769942	cg09225457	CHR 7, 8479893	0.0113
	rs2057862	cg02124383	CHR 7, 8475198	0.0396
		cg20378002	CHR 7, 8477029	0.0017
		cg08897422	CHR 7, 8666902	0.0247
		cg21001050	CHR 7, 8791686	0.0048
	rs10265408	cg06328127	CHR 7, 8469546	0.0327
	rs10273195 ^d	cg06981279	CHR 7, 8477156	0.0287
		cg06335867	CHR 7, 8482325	0.0467
		cg21806015	CHR 7, 8483249	0.0243
	rs12537067 ^d	cg01994275	CHR 7, 8480586	0.0466
	rs12537067 ^d	cg06328127	CHR 7, 8469546	0.0346
	rs7793115 ^d	cg22339356	CHR 7, 8473385	0.0435
	rs17406479 ^d	cg26170604	CHR 7, 8482614	0.0143
	rs10486228 ^d	cg20378002	CHR 7, 8477029	0.0435
	rs10486228 ^d	cg21001050	CHR 7, 8791686	0.0098
	rs17154569 ^d	cg13611822	CHR 7, 8483710	0.0447
cg06328127	rs17154569 ^d	CHR 7, 8469546	0.0298
rs6952383 ^d	cg00852549	CHR 7, 8473457	0.0464
	cg20378002	CHR 7, 8477029	0.0007
	cg23075337	CHR 7, 8481460	0.0102
	cg10443049	CHR 7, 8481537	0.0337
	cg12597389	CHR 7, 8482235	0.0331
	cg01933308	CHR 7, 8483569	0.0137
PHF17	rs4975270	cg19120496	CHR 4, 129731335	0.0493
		cg09164670	CHR 4, 129731835	0.0106
		cg26347359	CHR 4, 129759716	0.0069
	rs13148510	cg26766900	CHR 4, 129730719	0.0351
	rs13148510	cg11264547	CHR 4, 129731973	0.0399
	rs13143771	cg19120496	CHR 4, 129731335	0.0100
	rs13143771	cg26347359	CHR 4, 129759716	0.0095
	rs13142964	cg19120496	CHR 4, 129731335	0.0128
	rs11722830 ^d	cg14617908	CHR 4, 129730872	0.0139
		cg09164670	CHR 4, 129731835	0.0133
		cg22868951	CHR 4, 129767588	0.0468
	rs12505447 ^d	cg09164670	CHR 4, 129731835	0.0343
	rs12505447 ^d	cg09568483	CHR 4, 129753010	0.0337
	rs6534704 ^d	cg17503252	CHR 4, 129733028	0.0303
	rs6534704 ^d	cg26347359	CHR 4, 129759716	0.0472
MYB	rs210936	cg07363239	CHR 6, 135502390	0.0016
		cg11579069	CHR 6, 135502794	0.0187
		cg01369646	CHR 6, 135502875	0.0091
	rs17639758	cg18253802	CHR 6, 135501780	0.0411
	rs1013891	cg00366934	CHR 6, 135503837	0.0471
	rs1013891	cg10574148	CHR 6, 135504383	0.0117
	rs2179308	cg00366934	CHR 6, 135503837	0.0441

The GLM procedure (SAS v9.2) adjusted for age, sex and BMI was used to test for the associations between tagged SNPs and methylation levels; ^a CpG site positions according to genome build 37; ^b p Values are derived from log10-transformed data; ^c Heterozygotes were merged with rare homozygotes (dominant model); ^d GWAS hit identified in the FAS study; ^e SNP showed genotype or gene-diet interaction effects on plasma triglyceride levels. * p Value remained significant after controlling for false discovery rate (MULTTEST procedure, SAS v9.2).