Figure 3.

Teff from therapy-naïve MS patients induced a severe graft-versus-host disease (GvHD) without protection by activated Treg. (A) Treg-depleted PBMC from either MS patients or HC ± activated Treg from third healthy controls were transferred into newborn immunodeficient mice. Untreated mice served as controls. Each point represents the cumulative mean weight of one group ± SD of n = 5 mice in each group (left); survival of mice in Kaplan–Meier plot till day 45 is shown (right); (B) Shown are representative pictures of mice and abdominal organs 25 days after transfer; skin inflammation (left); clinical appearance of liver and intestine (right).